Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents.
Identifieur interne : 001567 ( Main/Exploration ); précédent : 001566; suivant : 001568Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents.
Auteurs : RBID : pubmed:21888430English descriptors
- KwdEn :
- Animals, Biological Transport, CHO Cells, Chelating Agents (chemistry), Cricetinae, Cricetulus, Gadolinium (chemistry), Indium (chemistry), Indium (diagnostic use), Indium (metabolism), Lanthanoid Series Elements (chemistry), Magnetic Resonance Imaging, Molecular Imaging (methods), Optical Processes, Organometallic Compounds (chemistry), Permeability, Phosphines (chemistry), Phosphines (diagnostic use), Phosphines (metabolism), Quantum Dots, Rats, Spectrometry, Fluorescence, Sulfides (chemistry), Surface Properties, Zinc Compounds (chemistry).
- MESH :
- chemical , chemistry : Chelating Agents, Gadolinium, Indium, Lanthanoid Series Elements, Organometallic Compounds, Phosphines, Sulfides, Zinc Compounds.
- chemical , diagnostic use : Indium, Phosphines.
- chemical , metabolism : Indium, Phosphines.
- methods : Molecular Imaging.
- Animals, Biological Transport, CHO Cells, Cricetinae, Cricetulus, Magnetic Resonance Imaging, Optical Processes, Permeability, Quantum Dots, Rats, Spectrometry, Fluorescence, Surface Properties.
Abstract
Quantum dots (QDs) are ideal scaffolds for the development of multimodal imaging agents, but their application in clinical diagnostics is limited by the toxicity of classical CdSe QDs. A new bimodal MRI/optical nanosized contrast agent with high gadolinium payload has been prepared through direct covalent attachment of up to 80 Gd(III) chelates on fluorescent nontoxic InP/ZnS QDs. It shows a high relaxivity of 900 mM(-1) s(-1) (13 mM(-1 )s(-1) per Gd ion) at 35 MHz (0.81 T) and 298 K, while the bright luminescence of the QDs is preserved. Eu(III) and Tb(III) chelates were also successfully grafted to the InP/ZnS QDs. The absence of energy transfer between the QD and lanthanide emitting centers results in a multicolor system. Using this convenient direct grafting strategy additional targeting ligands can be included on the QD. Here a cell-penetrating peptide has been co-grafted in a one-pot reaction to afford a cell-permeable multimodal multimeric MRI contrast agent that reports cellular localization by fluorescence and provides high relaxivity and increased tissue retention with respect to commercial contrast agents.
DOI: 10.1021/nn202839w
PubMed: 21888430
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents.</title><author><name sortKey="Stasiuk, Graeme J" uniqKey="Stasiuk G">Graeme J Stasiuk</name><affiliation wicri:level="3"><nlm:affiliation>CEA-Grenoble, INAC, SCIB, Laboratoire de Reconnaissance Ionique et Chimie de Coordination, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA-Grenoble, INAC, SCIB, Laboratoire de Reconnaissance Ionique et Chimie de Coordination, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Tamang, Sudarsan" uniqKey="Tamang S">Sudarsan Tamang</name></author><author><name sortKey="Imbert, Daniel" uniqKey="Imbert D">Daniel Imbert</name></author><author><name sortKey="Poillot, Cathy" uniqKey="Poillot C">Cathy Poillot</name></author><author><name sortKey="Giardiello, Marco" uniqKey="Giardiello M">Marco Giardiello</name></author><author><name sortKey="Tisseyre, Celine" uniqKey="Tisseyre C">Céline Tisseyre</name></author><author><name sortKey="Barbier, Emmanuel L" uniqKey="Barbier E">Emmanuel L Barbier</name></author><author><name sortKey="Fries, Pascal Henry" uniqKey="Fries P">Pascal Henry Fries</name></author><author><name sortKey="De Waard, Michel" uniqKey="De Waard M">Michel de Waard</name></author><author><name sortKey="Reiss, Peter" uniqKey="Reiss P">Peter Reiss</name></author><author><name sortKey="Mazzanti, Marinella" uniqKey="Mazzanti M">Marinella Mazzanti</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1021/nn202839w</idno><idno type="RBID">pubmed:21888430</idno><idno type="pmid">21888430</idno><idno type="wicri:Area/Main/Corpus">001172</idno><idno type="wicri:Area/Main/Curation">001172</idno><idno type="wicri:Area/Main/Exploration">001567</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Transport</term><term>CHO Cells</term><term>Chelating Agents (chemistry)</term><term>Cricetinae</term><term>Cricetulus</term><term>Gadolinium (chemistry)</term><term>Indium (chemistry)</term><term>Indium (diagnostic use)</term><term>Indium (metabolism)</term><term>Lanthanoid Series Elements (chemistry)</term><term>Magnetic Resonance Imaging</term><term>Molecular Imaging (methods)</term><term>Optical Processes</term><term>Organometallic Compounds (chemistry)</term><term>Permeability</term><term>Phosphines (chemistry)</term><term>Phosphines (diagnostic use)</term><term>Phosphines (metabolism)</term><term>Quantum Dots</term><term>Rats</term><term>Spectrometry, Fluorescence</term><term>Sulfides (chemistry)</term><term>Surface Properties</term><term>Zinc Compounds (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chelating Agents</term><term>Gadolinium</term><term>Indium</term><term>Lanthanoid Series Elements</term><term>Organometallic Compounds</term><term>Phosphines</term><term>Sulfides</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium</term><term>Phosphines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Indium</term><term>Phosphines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Transport</term><term>CHO Cells</term><term>Cricetinae</term><term>Cricetulus</term><term>Magnetic Resonance Imaging</term><term>Optical Processes</term><term>Permeability</term><term>Quantum Dots</term><term>Rats</term><term>Spectrometry, Fluorescence</term><term>Surface Properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quantum dots (QDs) are ideal scaffolds for the development of multimodal imaging agents, but their application in clinical diagnostics is limited by the toxicity of classical CdSe QDs. A new bimodal MRI/optical nanosized contrast agent with high gadolinium payload has been prepared through direct covalent attachment of up to 80 Gd(III) chelates on fluorescent nontoxic InP/ZnS QDs. It shows a high relaxivity of 900 mM(-1) s(-1) (13 mM(-1 )s(-1) per Gd ion) at 35 MHz (0.81 T) and 298 K, while the bright luminescence of the QDs is preserved. Eu(III) and Tb(III) chelates were also successfully grafted to the InP/ZnS QDs. The absence of energy transfer between the QD and lanthanide emitting centers results in a multicolor system. Using this convenient direct grafting strategy additional targeting ligands can be included on the QD. Here a cell-penetrating peptide has been co-grafted in a one-pot reaction to afford a cell-permeable multimodal multimeric MRI contrast agent that reports cellular localization by fluorescence and provides high relaxivity and increased tissue retention with respect to commercial contrast agents.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21888430</PMID><DateCreated><Year>2011</Year><Month>10</Month><Day>25</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>21</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1936-086X</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>10</Issue><PubDate><Year>2011</Year><Month>Oct</Month><Day>25</Day></PubDate></JournalIssue><Title>ACS nano</Title><ISOAbbreviation>ACS Nano</ISOAbbreviation></Journal><ArticleTitle>Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents.</ArticleTitle><Pagination><MedlinePgn>8193-201</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/nn202839w</ELocationID><Abstract><AbstractText>Quantum dots (QDs) are ideal scaffolds for the development of multimodal imaging agents, but their application in clinical diagnostics is limited by the toxicity of classical CdSe QDs. A new bimodal MRI/optical nanosized contrast agent with high gadolinium payload has been prepared through direct covalent attachment of up to 80 Gd(III) chelates on fluorescent nontoxic InP/ZnS QDs. It shows a high relaxivity of 900 mM(-1) s(-1) (13 mM(-1 )s(-1) per Gd ion) at 35 MHz (0.81 T) and 298 K, while the bright luminescence of the QDs is preserved. Eu(III) and Tb(III) chelates were also successfully grafted to the InP/ZnS QDs. The absence of energy transfer between the QD and lanthanide emitting centers results in a multicolor system. Using this convenient direct grafting strategy additional targeting ligands can be included on the QD. Here a cell-penetrating peptide has been co-grafted in a one-pot reaction to afford a cell-permeable multimodal multimeric MRI contrast agent that reports cellular localization by fluorescence and provides high relaxivity and increased tissue retention with respect to commercial contrast agents.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stasiuk</LastName><ForeName>Graeme J</ForeName><Initials>GJ</Initials><Affiliation>CEA-Grenoble, INAC, SCIB, Laboratoire de Reconnaissance Ionique et Chimie de Coordination, UMR-E 3 CEA-UJF, 38054 Grenoble Cedex 9, France.</Affiliation></Author><Author ValidYN="Y"><LastName>Tamang</LastName><ForeName>Sudarsan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Imbert</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Poillot</LastName><ForeName>Cathy</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Giardiello</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Tisseyre</LastName><ForeName>Céline</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Barbier</LastName><ForeName>Emmanuel L</ForeName><Initials>EL</Initials></Author><Author ValidYN="Y"><LastName>Fries</LastName><ForeName>Pascal Henry</ForeName><Initials>PH</Initials></Author><Author ValidYN="Y"><LastName>de Waard</LastName><ForeName>Michel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Reiss</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Mazzanti</LastName><ForeName>Marinella</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Nano</MedlineTA><NlmUniqueID>101313589</NlmUniqueID><ISSNLinking>1936-0851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Lanthanoid Series Elements</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Phosphines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Sulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Zinc Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>22398-80-7</RegistryNumber><NameOfSubstance>indium phosphide</NameOfSubstance></Chemical><Chemical><RegistryNumber>AU0V1LM3JT</RegistryNumber><NameOfSubstance>Gadolinium</NameOfSubstance></Chemical><Chemical><RegistryNumber>KPS085631O</RegistryNumber><NameOfSubstance>zinc sulfide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Biological Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">CHO Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cricetinae</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cricetulus</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gadolinium</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lanthanoid Series Elements</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Molecular Imaging</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Optical Processes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Organometallic Compounds</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Permeability</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Phosphines</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Quantum Dots</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Spectrometry, Fluorescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sulfides</DescriptorName><QualifierName 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